Monday, September 13, 2010

Pancreatic Cancer Symptoms And Disease Explanation

By Lucas Martin

This specific form of cancer is due to a malignant mass of tissue that is abnormal located inside the pancreas. Current US estimates indicate that nearly forty-three thousand people will be affected by it and more than thirty-six thousand will die from it before the end of 2010. One main issue is that it is so difficult to diagnose because pancreatic cancer symptoms are often not present until the late stages.

The pancreas regulates the way that the body processes sugar and it plays a major role in the digestive system. It supplies vital digestive juices that are required to digest food. When it develops cells that mutate and continue to live past regular life expectancy they accumulate causing cancer in the form of a tumor.

Because there are different types of cells, different types of cancer are also possible. A specific type of cell is responsible for only digestive juices and the other is related to hormone production. Each of these cell types can be associated with a specific type of cancer.

Cells responsible for digestive juices line ducts inside the organ. These particular cells are most often connected with adenocarcinomas. This group of cells may also be called an exocrine tumor.

Hormone producing cells located here are responsible for the production of insulin. When these cells become involved it is known as a form of endocrine cancer. Fortunately, this type is extremely rare and only affects a very small percentage of the population; under one percent.

Cancer of the pancreas is also referred to as the silent killer due to the symptoms being hidden until the condition is actually quite serious. Symptoms that most individuals experience are upper abdomen pain that goes through to back, weight loss, no appetite, depression, blood clots and yellowing of skin and around the white part of eyes.

It is possible for some of these symptoms to be related to other conditions, but most are cause for seeking medical attention. Testing will likely begin to establish the proper diagnosis. If cancer is present, the physician will decide at what stage and start required treatment.

Stages are categorized in one through four; four being the most critical. Stage one indicates the presence of cancer within the pancreas. Stage two includes the presence within and its spread to organs and tissue nearby with the possibility of the lymph nodes included. Stage three means that cancer has spread to major blood vessels nearby and possibly the lymph nodes. Stage four acknowledges the spread of disease well beyond and to other organs.

Surgery will most likely be the course of treatment if cancer has remained only in the pancreas when the diagnosis is delivered. Unfortunately, if it has spread to other areas then this may not be an option and medication may be the only form of treatment. The patient will be provided with medications to keep them comfortable while dealing with the symptoms. There is no specific way to avoid pancreatic cancer, but there are ways to assist in the prevention including avoiding smoking, keeping weight under control and exercising.

There are certain individuals who are more likely to develop this form of cancer. Individuals over the age of sixty are much more susceptible as well as those who suffer from diabetes and have a family history. It is advised for this group to pay closer attention to pancreatic cancer symptoms.

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Thursday, August 26, 2010

Pancreatic cancer research moving forward - Baylor College of Medicine

Pancreatic cancer research moving forward - Baylor College of Medicine

Monday, June 14, 2010

Understanding The Stages of Pancreatic Cancer

Understanding The Stages of Pancreatic Cancer

Understanding
 The Stages of Pancreatic Cancer
Pancreatic Cancer, also known as exocrine cancer, is a disease where malignant (cancer) cells appear in the tissues of the pancreas.
Uncontrolled multiplication of cells in the pancreas leads to pancreatic cancer. Explanations as to how one develops pancreatic cancer remain unexplained. But, it is not contagious. Over 29,000 people in the United States are diagnosed with the pancreatic cancer every year. Pancreatic cancer is treatable when caught early; but vast majority of cases are not diagnosed until too late. Five-year survival rates show 40 percent survival if the cancers are surgically removed while they have not grown in size and spread to the lymph nodes. What is stage IV cancer of the pancreas survival rate?
General research show that patients diagnosed with stage IV pancreatic cancer survive within a median of 6.8 months to a year upon diagnosis.

Sunday, June 6, 2010

Its Still Vaccination Against Germs,Not Cancer

The pharma huge marketing effort to promote vaccination against cancers have gotten parallel response from the governments and private health institutions.Hence,vaccines against Cervical cancers are available ubiquitously even in the economically weak third world countries.One may question the real value of this preventive measure as compared to the cheaper alternative like circumcision of the partners and living a healthy sexual lifestyle.
The idea of vaccinating against the development of cancer per se has been around for quite some time.The difference between vaccinating against a germ as compared to cancer is that of "clonality".
The germ's antigen/protein against which the antibodies are generated in the process of vaccination is usually homogeneous in nature ie.their structure are usually of one type.On the contrary,there are so many antigens/proteins that make up cancer cells ie they are polyclonal.Vaccination in this situation is extremely difficult.It is much easier in this situation to generate antibodies in vitro and then infuse these antibodies back into the patients as part of systemic treatment of an establish cancer patients.The latter is called Cellular Therapy of cancers.
However,the novel idea of primarily vaccinating against cancer is worth pursuing.
in reference to: http://news.bbc.co.uk/2/hi/health/8714085.stm (view on Google Sidewiki)

Monday, May 24, 2010

Surgery The Only Hope For Pancreatic Cancer

90% of Pancreatic Cancer is unresectable at the time of diagnosis. Only about 10% has the chance of surgery and hence cure at the time of diagnosis.That makes Pancreatic Cancer as one of the most feared Cancer to get. Having said that,we hear many people including celebrities who have been cured of Pancreatic Cancer by surgery.This is because Pancreatic Cancer is quite common in the community who are living the modern/western lifestyle.
Surgery is the main hope for cure.Other modalities of treatment are at best "experimental" in nature.
Nonetheless,a chemotherapeutic agent Gemcitabine has very promising outcome to improve in the success of treating pancreatic cancer.
The best chance of treating Pancreatic Cancer is to detect/discover them early even before the classical symptoms of jaundice appears.Patients with vague abdominal or back pain not responding to the usual treatment of abdominal and back pain should undergo a CT abdomen with a tumour marker study of CA19-9.
in reference to: http://www.cancerjournals.net/part-1-pancreatic-cancer-and-the-latest-treatments-ask-dr-patrick-g-jackson/ (view on Google Sidewiki)

Thursday, May 20, 2010

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Binge drinking linked to pancreatic cancer

A new research from UT Southwestern Medical Center suggests that heavy alcohol use and binge drinking can increase the risk of pancreatic cancer in men. 

Researchers found that men who consumed alcohol increased their risk of pancreatic cancer by 1.5 to 6 times compared with those who didn't consume alcohol or who had less than one drink per month.

Also, men who engaged in binge drinking had a 3.5 times greater likelihood of developing pancreatic cancer.

"If this relationship continues to be confirmed, reducing heavy and binge drinking may be more important than we already know," said Dr. Samir Gupta, assistant professor of internal medicine at UT Southwestern and lead author of the study, which was conducted at the University of California, San Francisco. 



source:http://timesofindia.indiatimes.com/Life/Health-Fitness/Health/Binge-drinking-linked-to-pancreatic-cancer/articleshow/5952739.cms


Saturday, May 15, 2010

In Patients With Pancreatic Disease, Quality-Of-Life Testing May Predict Malignancy And Survival

Quality-of-life measures used routinely to assess treatment outcomes for patients with pancreatic disease may be used to predict both malignancy and survival for those patients, according to a study by Henry Ford Hospital.

Researchers found that pre-treatment quality-of-life scores could predict malignancy in patients with pancreatic lesions and survival in those who are found to have malignancies.

"Our findings suggest that pretreatment quality-of-life scores may show which patients will have a poor survival and therefore could avoid aggressive, but futile, treatment," says Vic Velanovich, M.D., chief of General Surgery at Henry Ford Hospital and lead author of the study. 



Source :http://www.medicalnewstoday.com/articles/187555.php


Wednesday, May 5, 2010

How to Improve Pancreatic Cancer Life Expectancy

How to Improve Pancreatic Cancer Life Expectancy


Pancreatic cancer is a disease that primarily affects the pancreas. The pancreas is mostly located in the interior parts below the abdomen and the stomach. The pancreas is essential because it releases enzymes to catalyze the digestion process, and also helps maintain blood sugar levels stable.
Sadly, pancreatic cancer is rarely detected, and an effective treatment can be difficult to find. The symptoms of pancreatic cancer are usually felt at the peak of the disease—which gives the patient very little time to find a treatment.
The life expectancy of individuals who are diagnosed with pancreatic cancer is usually about five to eight months. Albeit pancreatic cancer life expectancy is very low, it is still possible to prolong the life expectancy of pancreatic cancer. The following information below shows a detailed guide on how to increase pancreatic cancer life expectancy, and how to treat pancreatic cancer symptoms.



Read more at Suite101: How to Improve Pancreatic Cancer Life Expectancy http://cancer.suite101.com/article.cfm/how-to-improve-pancreatic-cancer-life-expectancy#ixzz0n2bUupVV

Ulcerative colitis in men linked to increased risk for pancreatic cancer | HemOncToday

Ulcerative colitis in men linked to increased risk for pancreatic cancer | HemOncToday


Patients with inflammatory bowel disease had six times the risk for developing pancreatic neoplasia, and men with ulcerative colitis had five times the risk for developing pancreatic neoplasia in a prospective study of more than 2,800 patients.
Because there is a known association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis and cholangiocarcinoma within the bile ducts, as well as between primary sclerosing cholangitis and pancreatic cancer, researchers suspected that patients with IBD would be at greater risk for the development of pancreatic cancer.
To test their supposition, researchers prospectively examined 2,877 adults with IBD who were treated in the University of Utah Health System from January 1996 to December 2006. The IBD cohort was then matched to the Utah Cancer Registry and the Utah Population Database to determine the number of patients diagnosed with IBD and pancreatic cancer.

Friday, April 30, 2010

Pancreatic Cancer Prognosis

Push for progress on pancreatic cancer

Push for progress on pancreatic cancer

You won't see it on a billboard or targeted in a police blitz, but you're more likely to die of pancreatic cancer in Australia than from a road accident.
Pancreatic cancer claims five Australian lives every day as one of the nation's most lethal diseases and yet it has remained off the health radar - in part, because of the grim prognosis of sufferers and no significant development in treatment.
"Despite considerable research efforts into pancreatic cancer over the last decade, very little progress has been made in the treatment of this disease," says Professor David Goldstein, a medical oncologist and director of the Sydney-based GI CANCER Institute.

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Wednesday, April 28, 2010

Molecular marker could help spot pancreatic cancer early

Molecular marker could help spot pancreatic cancer early

CHAPEL HILL – Researchers at the University of North Carolina at Chapel Hill School of Medicine have identified a molecular marker of pancreatic cancer that may help spot the disease at its earliest stages, when it can be treated more successfully with surgery.
In a finding published April 26, 2010, in the online journal PLoS One, the researchers showed that a specific form of a protein called palladin is produced in large amounts in the "tumor nest," the cells that surround a pancreatic tumor.
By measuring the levels of this form of palladin in patient samples, doctors could have an improved way to screen for the deadly cancer, possibly catching it earlier than ever before, said senior study author Carol Otey, Ph.D., associate professor of cell and molecular physiology at UNC.
Otey is a member of the NC Translational and Clinical Sciences Institute (NC TRaCS), part of a collaborative effort of a national network of medical research institutions affiliated with the NIH Clinical and Translational Science Awards (CTSAs).
"The problem with pancreas cancer is it is almost never caught at an early stage," said Otey. "By the time a person develops suspicious symptoms, the disease has typically progressed too far. But if you can diagnose it early, it can be treated very effectively with surgery."

Sunday, April 25, 2010

What Are The Risk Factors For Pancreatic Cancer? | Health Tips

What Are The Risk Factors For Pancreatic Cancer? | Health Tips

Pancreatic cancer is currently the fifth most common form of cancer in the United States and is diagnosed in around 40,000 Americans each year. In most cases pancreatic cancer has an extremely poor survival outcome. Just 1 in 20 people diagnosed with pancreatic cancer will still be alive after five years.
The main reason pancreatic cancer has such a poor survival outcome is that the majority of cases are diagnosed when the cancer is at a very late stage. This is due to the non-specific symptoms associated with pancreatic cancer in its early stages. Early warning signs of pancreatic cancer include pain in the upper abdomen, jaundice, loss of appetite, and weight loss.
There are several risk factors that are known to affect an individuals probability of developing pancreatic cancer. While some of these cannot be changed, several can be influenced by sensible lifestyle and diet modifications.
Here are eleven of the more established risk factors for pancreatic cancer.

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Wednesday, April 21, 2010

Immunomedics Reports New Blood Test for Detecting Early Stage Pancreatic Cancer Correlates With Response to Clivatuzumab Tetraxetan Treatment - MarketWatch

Immunomedics Reports New Blood Test for Detecting Early Stage Pancreatic Cancer Correlates With Response to Clivatuzumab Tetraxetan Treatment - MarketWatch

Immunomedics, Inc. /quotes/comstock/15*!immu/quotes/nls/immu (IMMU 3.72, 0.00, 0.00%) , a biopharmaceutical company focused on developing monoclonal antibodies to treat cancer and other serious diseases, today reported that a new blood test using the Company's proprietary humanized antibody, clivatuzumab or PAM4, predicted a partial response in an initial set of patients treated with a combination of the antibody labeled with yttrium-90 (Y-90) and gemcitabine. Results were presented at the 101st Annual Meeting of the American Association for Cancer Research.
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Tuesday, April 13, 2010

Immunomedics to Report on Potential Cancer Therapy Products in 8 Presentations at 101st Annual AACR Meeting - MarketWatch

Immunomedics to Report on Potential Cancer Therapy Products in 8 Presentations at 101st Annual AACR Meeting - MarketWatch

MORRIS PLAINS, N.J., Apr 12, 2010 (GlobeNewswire via COMTEX) -- Immunomedics, Inc. /quotes/comstock/15*!immu/quotes/nls/immu (IMMU 3.69, +0.12, +3.36%) , a biopharmaceutical company focused on developing monoclonal antibodies to treat cancer and other serious diseases, today announced that eight presentations reporting on the Company's progress in diverse cancer therapy product candidates will be given at the 101st Annual Meeting of the American Association for Cancer Research (AACR), April 17 -- 21, 2010, in Washington, DC.
The spotlight of this year's presentations will be on pancreatic cancer, highlighted by a study correlating the results from a blood test for pancreatic cancer detection with responses to a radiolabeled antibody therapy. Additionally, the Company will introduce new antibody-drug conjugates (ADC) being studied in this cancer. (Please refer to the Company's press release at www.immunomedics.com/news_pdf/2010_PDF/PR01212010.pdf for more information on the new blood test).

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Saturday, April 10, 2010

Studies Show Soda Linked to Pancreatic Cancer

Studies Show Soda Linked to Pancreatic Cancer

A new study has found a new negative thing related to sodas. Researchers at the University of Minnesota’s School of Public Health decided to cull through data from the Singapore Chinese Health Study, assessing whether sugar-sweetened soft drinks and juices had a noticeable effect in a different population. They concluded: yes on soft drinks, no on juices. In fact, consumption of two or more soft drinks a week was linked to an 87% increase in the risk of pancreatic cancer.

Friday, April 9, 2010

Early diagnosis remains key for those who treat cancer patients | West Central Tribune | Willmar, Minnesota

Early diagnosis remains key for those who treat cancer patients | West Central Tribune | Willmar, Minnesota

If the outlook for pancreatic and liver cancer is to improve, earlier diagnosis needs to be one of the main strategies, say physicians who treat these patients.
“That’s where we can do some major changes in survival and life expectancy,” said Dr. Ahsan Bhatti, a gastroenterologist at Affiliated Community Medical Centers in Willmar.
How to manage these two formidable cancers was the focus this week of the annual cancer symposium, hosted by the Willmar Regional Cancer Center.

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Tuesday, April 6, 2010

Pancreatic cancer - Wikipedia, the free encyclopedia

Pancreatic cancer - Wikipedia, the free encyclopedia

Pancreatic cancer is a malignant neoplasm of the pancreas. Each year in the United States, about 42,470 individuals are diagnosed with this condition and 35,240 die from the disease.[1] The prognosis is relatively poor but has improved; the three-year survival rate is now about thirty percent, but less than 5 percent of those diagnosed are still alive five years after diagnosis. Complete remission is still rather rare.[2]
About 95% of exocrine pancreatic cancers are adenocarcinomas (M8140/3). The remaining 5% include adenosquamous carcinomas, signet ring cell carcinomas, hepatoid carcinomas, colloid carcinomas, undifferentiated carcinomas, and undifferentiated carcinomas with osteoclast-like giant cells.[3] Exocrine pancreatic cancers are far more common than endocrine pancreatic cancers (also known as islet cell carcinomas), which make up about 1% of total cases.[4][5]

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