Patients with inflammatory bowel disease had six times the risk for developing pancreatic neoplasia, and men with ulcerative colitis had five times the risk for developing pancreatic neoplasia in a prospective study of more than 2,800 patients.
Because there is a known association between inflammatory bowel disease (IBD) and primary sclerosing cholangitis and cholangiocarcinoma within the bile ducts, as well as between primary sclerosing cholangitis and pancreatic cancer, researchers suspected that patients with IBD would be at greater risk for the development of pancreatic cancer.
To test their supposition, researchers prospectively examined 2,877 adults with IBD who were treated in the University of Utah Health System from January 1996 to December 2006. The IBD cohort was then matched to the Utah Cancer Registry and the Utah Population Database to determine the number of patients diagnosed with IBD and pancreatic cancer.
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